Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology

Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically.
Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
Content:
Chapter 1 Introduction: Metabolic Hydrolysis and Prodrug Design (pages 1–9):
Chapter 2 Classification, Localization, and Some Physiological Roles of Hydrolytic Enzymes (pages 11–46):
Chapter 3 Catalytic Mechanisms of Hydrolytic Enzymes (pages 47–79):
Chapter 4 The Hydrolysis of Amides (pages 81–162):
Chapter 5 The Hydrolysis of Lactams (pages 163–234):
Chapter 6 The Hydrolysis of Peptides: Sections 6.1 – 6.3 (pages 235–311):
Chapter 6 The Hydrolysis of Peptides: Sections 6.4 – 6.6 (pages 312–364):
Chapter 7 The Hydrolysis of Carboxylic Acid Esters (pages 365–418):
Chapter 8 The Hydrolysis of Carboxylic Acid Ester Prodrugs (pages 419–534):
Chapter 9 The Cleavage of Esters of Inorganic Acids (pages 535–590):
Chapter 10 The Hydration of Epoxides (pages 591–661):
Chapter 11 Miscellaneous Reactions of Hydration and Dehydration (pages 663–748):
Chapter 12 Conclusion: The Biochemistry of Water (pages 749–751):